[2-hydroxy-5-[3-[(3-oxo-3-sodiooxy-propyl)carbamoyl]phenyl]azo-benzoyl]oxysodium
Balsalazide disodium
CAS: 213594-60-6;82101-18-6
Molecular Formula: C17H13N3Na2O6
[2-hydroxy-5-[3-[(3-oxo-3-sodiooxy-propyl)carbamoyl]phenyl]azo-benzoyl]oxysodium - Names and Identifiers
[2-hydroxy-5-[3-[(3-oxo-3-sodiooxy-propyl)carbamoyl]phenyl]azo-benzoyl]oxysodium - Physico-chemical Properties
| Molecular Formula | C17H13N3Na2O6 |
| Molar Mass | 401.28 |
| Storage Condition | 2-8℃ |
[2-hydroxy-5-[3-[(3-oxo-3-sodiooxy-propyl)carbamoyl]phenyl]azo-benzoyl]oxysodium - Standard
Authoritative Data Verified Data
This product is (E)-5-[[4-[(2-carboxyethyl) carbamoyl] phenyl] azo] Salicylic acid disodium salt dihydrate. The content of C17H13N3Na206 shall be 98.0% to 102.0% based on the calculation of water-free and solvent-free substances.
Last Update：2024-01-02 23:10:35
[2-hydroxy-5-[3-[(3-oxo-3-sodiooxy-propyl)carbamoyl]phenyl]azo-benzoyl]oxysodium - Trait
Authoritative Data Verified Data
- This product is yellow or orange-yellow crystalline powder; Odorless, with hygroscopicity.
- This product is soluble in water, soluble in methanol, slightly soluble in glacial acetic acid, and almost insoluble in ethanol or chloroform.
Last Update：2022-01-01 11:33:10
[2-hydroxy-5-[3-[(3-oxo-3-sodiooxy-propyl)carbamoyl]phenyl]azo-benzoyl]oxysodium - Differential diagnosis
Authoritative Data Verified Data
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- take an appropriate amount of this product, add water to dissolve and dilute to prepare a solution containing about 10ug per lml, and measure it by UV-Vis spectrophotometry (General rule 0401), there is a maximum absorption at 261nm and 357nm wavelengths, and a minimum absorption at a wavelength of 289nm.
- The infrared absorption spectrum of this product should be consistent with that of the reference product (General rule 0402).
- This product shows the reaction of sodium salt identification (1) (General rule 0301).
Last Update：2022-01-01 11:33:10
[2-hydroxy-5-[3-[(3-oxo-3-sodiooxy-propyl)carbamoyl]phenyl]azo-benzoyl]oxysodium - Exam
Authoritative Data Verified Data
alkalinity
take this product (0.10g, add water 30ml to dissolve, according to the law to determine (General 0631),pH value should be 7.0~9.0.
Related substances
take an appropriate amount of this product, accurately weigh it, add the mobile phase to dissolve and dilute to make a solution containing about 0.3mg per lml, as a test solution; Take lml for precision, set in a 100ml measuring flask, dilute to the scale with the mobile phase, and shake to serve as a control solution. In addition to the detection wavelength of 240nm, according to the chromatographic conditions under the content determination item, 20 u1 of the control solution and the test solution were accurately measured, and the human liquid chromatograph was injected respectively, the chromatogram was recorded to 4 times the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (0.5%) the area of the main peak of the control solution, and the sum of the areas of each impurity peak shall not be greater than the area of the main peak of the control solution (1.0%).
residual solvent
precision weighing this product l.O g, put it in a 50ml measuring flask, add water to dissolve and dilute to the scale, shake well, take 5ml accurately, place it in the top empty bottle, seal it, and use it as a test solution; precision weighing the right amount of anhydrous ethanol, water quantitative dilution made per lml containing 0.1 mg of the solution, 5ml of which was precisely weighed, was placed in a headspace bottle, and sealed as a reference solution. According to the determination method of residual solvent (General Principle 0861 second method), the capillary column with 6% cyanopropyl phenyl-94% dimethyl polysiloxane (or similar polar) as stationary liquid is used as the column; The initial temperature is 30°C, hold for 5 minutes, raise the temperature to 80°C at a rate of 2°C per minute, then raise the temperature to 200°C at a rate of 30°C per minute for 5 minutes; The detector temperature is 200°C, the inlet temperature was 180°C; The headspace bottle equilibration temperature was 80°C and the equilibration time was 30 minutes. The test solution and the reference solution were injected by Headspace, and the chromatograms were recorded. According to the external standard method to calculate the peak area, the residual amount of ethanol should comply with the provisions.
moisture
take this product, according to the moisture determination method (General 0832 first method), the moisture content should be 8.0% ~ 10.0%.
Heavy metals
This product l.Og, inspection according to law (General Principles 0821 second law), containing heavy metals shall not exceed 20 parts per million.
Last Update：2022-01-01 11:33:11
[2-hydroxy-5-[3-[(3-oxo-3-sodiooxy-propyl)carbamoyl]phenyl]azo-benzoyl]oxysodium - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
chromatographic conditions and system suitability test
silica gel bonded with a Eighteen alkyl silane as a filler; O.Olmol/L potassium dihydrogen phosphate solution (0.1 mol/L potassium hydroxide solution to adjust the pH value to 6.8)-methanol (60:40) as mobile phase; The detection wavelength was 361nm. The number of theoretical plates shall not be less than 2000 based on the balsalazide sodium peak.
assay
take an appropriate amount of this product, accurately weigh it, add the mobile phase to dissolve and quantitatively dilute it to make a solution containing about 15ug per lml, which is used as the test solution, accurately take lOpl injection liquid chromatograph, record chromatogram; Another balsalazide sodium reference substance, the same method for determination. According to the external standard method to calculate the peak area, that is.
Last Update：2022-01-01 11:33:12
[2-hydroxy-5-[3-[(3-oxo-3-sodiooxy-propyl)carbamoyl]phenyl]azo-benzoyl]oxysodium - Category
Authoritative Data Verified Data
therapeutic agents for inflammatory bowel disease.
Last Update：2022-01-01 11:33:12
[2-hydroxy-5-[3-[(3-oxo-3-sodiooxy-propyl)carbamoyl]phenyl]azo-benzoyl]oxysodium - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:33:12
[2-hydroxy-5-[3-[(3-oxo-3-sodiooxy-propyl)carbamoyl]phenyl]azo-benzoyl]oxysodium - Reference Information
| use | anti-ulcerative colitis drugs. |
Last Update：2024-04-10 22:29:15
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CAS: 213594-60-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: Balsalazide disodium Visit Supplier Webpage Request for quotationCAS: 213594-60-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: Balsalazide disodium Visit Supplier Webpage Request for quotation
CAS: 213594-60-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 213594-60-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
[2-hydroxy-5-[3-[(3-oxo-3-sodiooxy-propyl)carbamoyl]phenyl]azo-benzoyl]oxysodium
881041-40-3
5,5-Dichloro-4-(chlorodifluoromethyl)-5-fluoro-4-hydroxy-2-pentanone oxime
3-Amino-1-methylpyridin-2(1H)-one
1H-Pyrrolo]1,2-c]imidazol-1-one,hexahydro-2-propyl-(8CI)
[(4S)-4,4a,5,6,7,8,8aα,9-Octahydro-6β-acetoxy-3,4aβ,5β-trimethyl-9-oxonaphtho[2,3-b]furan-4β-yl]2,3-dimethyloxirane-2-carboxylate
194427-58-2
3-Tolylmagnesium chloride
3,4-dimethyl-6-[(pentylamino)carbonyl]-3-cyclohexene-1-carboxylic acid
(E)-3-(3-Fluorophenyl)-1-(pyridin-2-yl)prop-2-en-1-one
881041-40-3
5,5-Dichloro-4-(chlorodifluoromethyl)-5-fluoro-4-hydroxy-2-pentanone oxime
3-Amino-1-methylpyridin-2(1H)-one
1H-Pyrrolo]1,2-c]imidazol-1-one,hexahydro-2-propyl-(8CI)
[(4S)-4,4a,5,6,7,8,8aα,9-Octahydro-6β-acetoxy-3,4aβ,5β-trimethyl-9-oxonaphtho[2,3-b]furan-4β-yl]2,3-dimethyloxirane-2-carboxylate
194427-58-2
3-Tolylmagnesium chloride
3,4-dimethyl-6-[(pentylamino)carbonyl]-3-cyclohexene-1-carboxylic acid
(E)-3-(3-Fluorophenyl)-1-(pyridin-2-yl)prop-2-en-1-one